Prior to the completion of NJ 21, Lexington Avenue ran directly into US 46; the service road along US 46 in Clifton is still known as Lexington Avenue.
Today, the first several blocks of Lexington Avenue, up to Hoover Avenue, are one-way northbound.
| Mile | Street Name | Feature (South to North) |
| 0.00 | CR 625 BEGINS, Passaic City | |
| 0.00 | Lexington Ave | Main Ave, CR 601 |
| 0.08 | Lexington Ave | (Central Ave, CR 624) [Madison St] {signal} |
| 0.16 | Lexington Ave | Monroe St {signal} |
| 0.48 | Lexington Ave | Harrison St {signal} |
| 0.72 | Lexington Ave | Highland Ave, [CR 626] |
| 0.72 | Entering (Passaic City) [Clifton City] | |
| 0.74 | Entering Clifton City | |
| 0.84 | Lexington Ave | [Center St] {signal} |
| 0.89 | Lexington Ave | Weasel Brook {bridge} |
| 0.96 | Lexington Ave | [Ackerman Ave] {signal} |
| 0.98 | Lexington Ave | [Kulik St] {signal} |
| 1.10 | Lexington Ave | Clifton Ave, CR 611 {signal} |
| 1.54 | Lexington Ave | (Piaget Ave, CR 628) {signal} |
| 1.69 | Lexington Ave | (Trimble Ave | Ramp to US 46 eastbound) [Randolph Ave, CR 627] {signal} |
| 1.69 | CR 625 ENDS, Clifton City | |